Juventus defender Daniele Rugani and midfielder Kwadwo Asamoah are expected to be out of action for more than seven weeks after suffering right knee injuries in the 1-0 win over Palermo on Saturday.
Scans revealed that Ghanaian Asamoah had ruptured his meniscus cartilage, while Rugani strained his lateral collateral ligament, the club said in a statement on Sunday.
Asamoah and Rugani will miss at least nine matches, including Wednesday's Champions League clash against Dinamo Zagreb in Croatia.
Juventus are top of Serie A with 15 points after the first six games of the season, one point ahead of second-placed Napoli.
(Reporting by Marianna Ciabach-Malinowska in Gdynia, editing by Nick Mulvenney)
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